Trevena Publicizes TRV045 Preclinical Data

June 20, 2024

DENVER, Colo., Jun 20, 2024 (247marketnews.com)- Trevena, Inc. (Nasdaq:TRVN) reported preclinical data from two separate research experiments, examined the cellular mechanism of analgesic effects of TRV045, conducted in collaboration with scientists at Virginia Commonwealth University and presented at the recent annual meeting of the American Society for Pharmacology and Experimental Therapeutics in May 2024, and a second set of studies from a separate, ongoing collaboration, with the NIH-supported Epilepsy Therapy Screening Program (ETSP).

“TRV045 showed clear and sustained analgesic-like properties in animal models of neuropathic pain, while showing no evidence of peripheral lymphopenia,” commented Dana Selley, PhD, Professor of Pharmacology and Toxicology at Virginia Commonwealth University. “Our studies provide molecular insights into these actions and demonstrate that TRV045 behaves differently from current S1P modulators such as fingolimod at the S1P1 receptor in CNS pain processing centers, where TRV045 caused neither desensitization of receptor function nor downregulation of receptor protein. These data suggest that TRV045 exerts its efficacy through agonist signaling.”

“The data observed with TRV045 in the ETSP study program showed a clear and strong anticonvulsant effect across a range of animal models. Current pharmacotherapy options in epilepsy are limited by incomplete anti-seizure medication efficacy and tolerance”, stated Alexander Rotenberg, MD, PhD, Professor of Neurology at Boston Children’s Hospital and Harvard Medical School. “With its unique mechanism of action, TRV045 has the potential to open an important new approach to epilepsy treatment.”

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