LIXTE Biotechnology Issues Corporate Update Amid Strategic Advancements and Scientific Validation

August 18, 2025

$6.5 Million Raised, Nasdaq Compliance Regained, New Board Members Appointed, Launches New Pre-Clinical Study, and Breakthrough Findings Published in Nature

DENVER, Colo., Aug 18, 2025 (247marketnews.com)- LIXTE Biotechnology (NASDAQ:LIXT) announced a series of key corporate and scientific developments, underscoring progress across financial, regulatory, clinical, and research fronts.

With clinical trials underway across prestigious institutions and a pipeline led by its lead compound LB-100, LIXTE continues to advance its mission of enhancing both chemotherapy and immunotherapy efficacy by targeting the PP2A pathway—a cellular regulator implicated in cancer resistance.

Key Developments:

Financing Success and Nasdaq Compliance– The company successfully completed two separate financings, including a private placement with accredited investors yielding $5 million in gross proceeds and a registered direct offering adding an additional $1.5 million.

These combined $6.5 million in fresh capital will support general corporate operations and clinical development efforts. Importantly, the financings also enabled LIXTE to regain full compliance with Nasdaq Capital Market listing requirements, restoring financial stability and investor confidence.

Leadership and Governance Enhancements– LIXTE announced significant leadership transitions, as Geordan Pursglove was named Chairman and CEO in June and Bas van der Baan, the former CEO, now serves as President and Chief Scientific Officer.

The company also expanded its Board, by adding Jason Sawyer and Michael Holloway, MD.
These new independent directors replace Stephen Forman, MD, and Yun Yen, MD, both of whom have transitioned to roles on a newly established Scientific Advisory Committee (SAC), which also includes Bas van der Baan and René Bernards, PhD, current board member.

This committee aims to guide scientific strategy as LIXTE advances its oncology pipeline.

Landmark Scientific Validation Published in Nature– In a significant scientific milestone, Nature published new findings that support the therapeutic rationale behind LIXTE’s ongoing trials with LB-100, its lead PP2A inhibitor (Read the study).

Conducted by Dr. Amir Jazaeri and his team at MD Anderson Cancer Center, the study revealed that patients with tumors harboring inactivating mutations in PPP2R1A, the scaffold subunit of PP2A, demonstrated significantly improved overall survival when treated with immune checkpoint inhibitors. These insights bolster the relevance of LIXTE’s mechanistic approach and validate LB-100’s potential to enhance immunotherapy response in multiple tumor types.

New Preclinical Study Aims at Cancer Prevention– LIXTE has launched a new preclinical collaboration with the Netherlands Cancer Institute (NKI) to explore the potential of LB-100 in cancer prevention. The study focuses on whether “initiated” cells, those harboring cancer-associated mutations, can be selectively eliminated using LB-100. This research could open entirely new indications for early-stage intervention.

Clinical Trials in Progress

LIXTE currently has ongoing clinical trials at MD Anderson Cancer Center and Northwestern University (ovarian cancer), with support from GSK and the Netherlands Cancer Institute (colorectal cancer), backed by F. Hoffmann-La Roche.

These studies reflect growing pharmaceutical and academic interest in the role of PP2A inhibition as a strategy to overcome resistance to standard cancer treatments.

With fresh capital, renewed Nasdaq compliance, and compelling data published in one of science’s most prestigious journals, LIXTE appears well-positioned to enter its next phase of development. The addition of seasoned leadership and scientific advisors further strengthens the company’s foundation as it eyes broader clinical validation for LB-100.

The company’s efforts to not only treat cancer but potentially prevent its progression through early intervention represents a bold and ambitious direction, one that could elevate LIXTE from a niche innovator to a transformational player in the oncology space.

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