Immatics Reports Interim Clinical Data for Ongoing Phase 1b ACTengine IMA203 TCR-T Trail

May 2, 2023

(24/7 MARKET NEWS) – Immatics N.V. (NASDAQ:IMTX) announced, this morning, interim clinical data update for 11 patients with recurrent and/or refractory solid cancers treated with ACTengine® IMA203 TCR-T monotherapy in the ongoing Phase 1b dose expansion Cohort A. IMA203 TCR-T cells are directed against an HLA-A*02-presented peptide derived from PRAME, a broadly expressed solid cancer target with clinical proof-of-concept for IMA203 demonstrated by Immatics in 2022. Overall, IMA203 showed a high rate of deep and durable objective responses, with a confirmed objective response rate of 67% (6/9), across multiple tumor types, including two confirmed partial responses (cPR) ongoing at more than 9 months after treatment and three additional partial responses ongoing at data cut-off. IMA203 monotherapy continues to be well tolerated in heavily pre-treated patients at doses of up to approximately 9 billion CD8+ TCR-T cells. No high-grade cytokine release syndrome (CRS) and no immune effector cell associated neurotoxicity syndrome (ICANS) were observed in Cohort A at data cut-off.

Immatics is trading at $9.07, up $1.75 (+23.90%), on 227K premarket shares traded.

Its 52-week range is $5.75 to $13.60. If the trading volume picks up, it could challenge the $11-12 trading range.

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