ORIC Pharmaceuticals Announces Multiple Clinical Collaborations with Strategic Partners to Support Ongoing ORIC-944 Trials

July 17, 2024

DENVER, Colo., Jul 17, 2024 (247marketnews.com)- ORIC Pharmaceuticals, Inc. (Nasdaq:ORIC) stated it initiated ORIC-944 dosing this year, in combination with darolutamide as well as in combination with apalutamide, as part of the ongoing Phase 1b trial in patients with metastatic prostate cancer.

Jacob M. Chacko, M.D., ORIC’s president and CEO, commented, “We are pleased to enter into these clinical collaborations to investigate the broader potential of ORIC-944 in combination with AR inhibitors, a combination approach that we believe is particularly promising based on our preclinical findings as well as emerging clinical data.

“As reported at the AACR Annual Meeting earlier this year, the combination of ORIC-944 and AR inhibitors demonstrated synergy in multiple prostate cancer models with a unique mechanism of reprogramming prostate cancer to revert to an AR-dependent state. Together with the emerging clinical profile of ORIC-944, which has already demonstrated superior clinical half-life, robust target engagement and favorable safety as a monotherapy, the combination of ORIC-944 with an AR inhibitor has the potential to become a novel treatment paradigm for patients with prostate cancer.”

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