24/7 Market News- Sangamo Therapeutics Entered Global Epigenetic Regulation and Capsid Delivery License Agreement with Genentech
DENVER, Colo., Aug 06, 2024 (247marketnews.com)- Sangamo Therapeutics, Inc. (Nasdaq: SGMO) entered into a license agreement with Genentech, a member of the Roche Group (OTCQX: RHHBY), to develop intravenously administered genomic medicines to treat certain neurodegenerative diseases, in which Sangamo grants Genentech an exclusive license to Sangamo’s proprietary zinc finger repressors that are directed to the tau gene, which is critically involved in Alzheimer’s disease and other tauopathies, as well as an undisclosed second neurology target.
Sangamo’s CEO, Sandy Macrae, commented, “Sangamo has been pioneering the field of genomic medicine for years to address devastating neurodegenerative diseases with limited current treatment options.
“We strongly believe in the power of our zinc finger technology to regulate the expression of key genes involved in disease. The recent discovery of our industry-leading intravenously delivered AAV capsid, STAC-BBB, has the potential to address longstanding challenges in delivering therapeutics to the central nervous system. We are excited to share this powerful combination with Genentech to advance potential treatment options for devastating neurodegenerative disorders, and we are hopeful this could be the first of multiple capsid collaborations to come with other partners.”
Sangamo expects to receive $50 million in near-term upfront payments and is eligible to earn up to $1.9 billion in total.
Roche’s Head of Corporate Business Development, Boris L. Zaïtra, added, “We are uniquely positioned with our collective experience, expertise and resources in neurological research to explore transformative approaches, including gene therapy, that treat neurodegenerative diseases.
“Through groundbreaking research and partnerships with companies such as Sangamo, we are committed to pursuing important breakthroughs in both early diagnosis and treatment. Our relentless pursuit of scientific innovation is taking us into areas of enormous unmet medical need and progress in treating diseases of the brain and nervous system.”
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