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Immutep to Announce New TACTI-002 Data in an Oral Presentation at the ASCO 2022 Annual Meeting

Immutep to Announce New TACTI-002 Data in an Oral Presentation at the ASCO 2022 Annual Meeting

SYDNEY, AUSTRALIA, April 28, 2022 (GLOBE NEWSWIRE) — Immutep Limited (ASX:IMM; NASDAQ:IMMP) (“Immutep or the Company), a biotechnology company developing novel LAG-3-related immunotherapy treatments for cancer and autoimmune disease, announces new interim data from first line non-small cell lung cancer patients (Part A) of the Phase II TACTI-002 trial has been selected for a prestigious Oral Presentation at the American Society of Clinical Oncologys (ASCO) 2022 Annual Meeting.

In addition, the Phase IIb TACTI-003 trial design will be presented in a Trial-in-Progress Poster Presentation.

ASCOs 2022 Annual Meeting will take place in-person and online from 3-7 June 2022 in Chicago, United States.

Abstracts for the presentations will be available from 5 pm US Eastern Time on 26 May 2022, and the presentations will be released on at the times indicated below and will subsequently be made available on Immuteps website. The TACTI-002 presentation will contain new and updated data that are not part of the abstract.

TACTI-002 Oral Presentation
Title: A Phase II study (TACTI-002) in 1st line metastatic non-small cell lung carcinoma investigating eftilagimod alpha (soluble LAG-3 protein) and pembrolizumab: updated results from a PD-L1 unselected population
Session Title:Oral Abstract Session/ Lung Cancer – Non-Small Cell Metastatic
Date:Friday, June 3, 2022, 1:00 PM-4:00 PM CDT
Presenter:Dr. Enriqueta Felip, Vall dHebron Institute of Oncology (VHIO), Barcelona, Spain
Abstract #:9003

TACTI-003 Poster Presentation
Title:TACTI-003: A randomized Phase IIb study of eftilagimod alpha (soluble LAG-3 protein) and pembrolizumab as first-line treatment of patients with recurrent or metastatic head and neck squamous-cell carcinoma
Session Title:Poster Session/Head and Neck Cancer
Date:Monday, June 6, 2022, 1:15 PM-4:15 PM CDT
Presenter:Dr. Douglas Adkin, Washington University School of Medicine, St Louis, Missouri, USA
Abstract #:TPS6099

About ASCO 2022
ASCOs annual meeting represents the worlds largest gathering of oncology physicians, industry representatives, researchers, patient advocates, and investment analysts to discuss cutting-edge clinical research and therapeutics in oncology, and to gain insights for improving cancer care. More than 40,000 attendees from around the world are expected to attend in person and online to stay up to date on new clinical cancer advances in every area of cancer research and gain real-time insights from world-renowned faculty. For additional information on the 2022 ASCOs Annual meeting, please visit https://www.asco.org/.

About TACTI-002
TACTI-002 (Two ACTive Immunotherapies) is a Phase II clinical trial being conducted in collaboration with Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside the United States and Canada). The study is evaluating the combination of Immuteps eftilagimod alpha with MSDs KEYTRUDA (pembrolizumab) in up to 183 patients with second line head and neck squamous cell carcinoma (HNSCC) or non-small cell lung cancer (NSCLC) in first and second line.

About TACTI-003
TACTI-003 is a Phase IIb clinical trial being conducted in collaboration with Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside the United States and Canada). The trial will evaluate Immuteps eftilagimod alpha in combination with MSDs KEYTRUDA (pembrolizumab) as a first line therapy in unresectable recurrent or metastatic HNSCC patients with PD-L1 negative (CPS 1) and PD-L1 positive (CPS 1) tumors. It will be a randomised, controlled clinical study in approximately 154 first line HNSCC patients and will take place across Australia, Europe and the United States in up to 35 clinical sites.

About Immutep
Immutep is a globally active biotechnology company that is a leader in the development of LAG-3 related immunotherapeutic products for the treatment of cancer and autoimmune disease. Immutep is dedicated to leveraging its technology and expertise to bring innovative treatment options to market for patients and to maximize value to shareholders. Immutep is listed on the Australian Securities Exchange (IMM), and on the NASDAQ (IMMP) in the United States.

Immuteps current lead product candidate is eftilagimod alpha (efti or IMP321), a soluble LAG-3 fusion protein (LAG-3Ig), which is a first-in-class antigen presenting cell (APC) activator being explored in cancer and infectious disease. Immutep is also developing an agonist of LAG-3 (IMP761) for autoimmune disease. Additional LAG-3 products, including antibodies for immune response modulation, are being developed by Immuteps large pharmaceutical partners.

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