Biotech Breakthroughs and AI War Chests Drive Late-Day Surge

DENVER, Colo., Oct 07, 2025 (247marketnews.com)- With just one hour left in the trading day, momentum is building behind a wave of innovation-centric small and mid-cap names, as investors are rotating into high-conviction growth stories heading into the close.

Telomir Pharmaceuticals (NASDAQ:TELO) surged after announcing new preclinical results that suggest its lead candidate Telomir-1 may reverse DNA methylation in aggressive prostate cancer models. The compound restored activity of two critical tumor suppressor genes, MASPIN and RASSF1A, which are often silenced in metastasis and chemo-resistant cancers. This could mark a new era in medicine, said CEO Erez Aminov, positioning Telomir-1 not just as a treatment but as a potential epigenetic reset therapy. Investors are watching closely for further updates on clinical development and expanded indications.

VENU (NYSE:VENU) continues to turn heads as it reshapes the concert and venue industry. Country music star Dierks Bentley joined the company as a founding advisor and shareholder, giving a vote of confidence to its hybrid model combining live entertainment, real estate, and digital fan engagement. With a $1.3 billion development pipeline and a 40-venue target by 2030, VENU is being billed by ThinkEquity analysts as a “blueprint for a new asset class,” who raised their price target to $18.

Spruce Biosciences (NASDAQ:SPRB) lit up the biotech boards after the FDA granted Breakthrough Therapy Designation to its enzyme replacement therapy for Sanfilippo Syndrome Type B, sending shares rocketing higher yesterday. In contrast, Galecto (NASDAQ:GLTO) is rallying on sentiment and speculation as it works toward an IND filing for GB3226 in Q1 2026. GLTO reported ~$10M in cash and remains one to watch for potential after-hours news or financing deals.

POET Technologies (NASDAQ:POET) closed a $75 million private placement with a single institutional investor — the largest in its history — aimed at accelerating growth in AI connectivity. CEO Dr. Suresh Venkatesan emphasized the opportunity in light sources for chip-to-chip communication and ultra-high-speed optical transceivers. “With a war chest of over $150 million and no significant debt,” he said, POET is poised to scale innovation across AI, photonics, and advanced data infrastructure.

Richtech Robotics (NASDAQ:RR), a key player in commercial service robotics, remains on radar following ongoing demand for automation solutions in hospitality and logistics. Investors are watching for contract wins and expanded deployments as RR continues its push into North American markets.

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